Mo Gaffney hosted two of her own television talk shows: Women Aloud! (which was shown on the Drop Dead Gorgeous.
Gaffney appeared on the British television talk show "The Full Wax" starring Ruby Wax, in which she portrayed American correspondent "Taffy Turner", in the recurring segment "Taffy Turner: Inside America".
Gaffney went on to team up with Jennifer Saunders with a recurring role as Bo in the sitcom Absolutely Fabulous; in 2004, talks of a spin-off show began but nothing surfaced. She is co-host of the "Women Aloud" radio program on Greenstone Media.
Gaffney is from San Diego, California. She is also an activist for same-sex marriage and has officiated at same-sex marriages as a certified marriage celebrant.